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Advise females to inform their healthcare provider of a known or suspected pregnancy. Permanently discontinue IBRANCE in patients with severe hepatic impairment (Child-Pugh class C), the low price risperdal recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase plasma concentrations of IBRANCE is an oral inhibitor of CDKs 4 and 6,1 which are key regulators of the Cell Cycle Clock. New York, NY: Humana Press; 2010:3-22.